Genetic Selection of Low Fertile Onchocerca volvulus by Ivermectin Treatment
نویسندگان
چکیده
منابع مشابه
Genetic Selection of Low Fertile Onchocerca volvulus by Ivermectin Treatment
BACKGROUND Onchocerca volvulus is the causative agent of onchocerciasis, or "river blindness". Ivermectin has been used for mass treatment of onchocerciasis for up to 18 years, and recently there have been reports of poor parasitological responses to the drug. Should ivermectin resistance be developing, it would have a genetic basis. We monitored genetic changes in parasites obtained from the s...
متن کاملIvermectin Resistance in Onchocerca volvulus: Toward a Genetic Basis
Onchocerciasis (river blindness) is a human disease caused by the filarial worm Onchocerca volvulus. Adult worms can live for over a decade in skin nodules of affected humans, releasing millions of microfilariae that cause debilitating itching and blindness [1]. An estimated 37 million people are infected [2], and there are 46,000 new cases of blindness annually (http://www.apoc.bf/). Internati...
متن کاملP-glycoprotein-like protein, a possible genetic marker for ivermectin resistance selection in Onchocerca volvulus.
Ivermectin (IVM) is the only safe drug for mass-treatment of onchocerciasis. IVM resistance has been reported in gastrointestinal nematode parasites of animals. A reduction in response to IVM in Onchocerca volvulus could have significant consequences for the onchocerciasis control programs. We have found evidence that, in O. volvulus, repeated IVM treatment selects for specific alleles, of P-gl...
متن کاملPhenotypic Evidence of Emerging Ivermectin Resistance in Onchocerca volvulus
BACKGROUND Ivermectin (IVM) has been used in Ghana for over two decades for onchocerciasis control. In recent years there have been reports of persistent microfilaridermias despite multiple treatments. This has necessitated a reexamination of its microfilaricidal and suppressive effects on reproduction in the adult female Onchocerca volvulus. In an initial study, we demonstrated the continued p...
متن کاملA comparison of genetic polymorphism in populations of Onchocerca volvulus from untreated- and ivermectin-treated patients.
An analysis of the polymorphism of 16 genes from Onchocerca volvulus was undertaken, in two populations of worms from either ivermectin-naïve patients or patients who had been repeatedly treated with ivermectin, in Ghana. Six genes were selected for analysis because studies in other nematodes had suggested a possible association with ivermectin resistance. The other 10 genes were included as co...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: PLoS Neglected Tropical Diseases
سال: 2007
ISSN: 1935-2735
DOI: 10.1371/journal.pntd.0000072